Evaluation of cardiovascular morbidities in children and adolescents with lupus nephritis from south India: A cross-sectional analytical study
Authors' conclusion
South Indian children with LN of >1 year disease duration demonstrate significant cardiovascular comorbidities, including evidence of endothelial dysfunction, as well as LV systolic and diastolic dysfunction.
Study context
- Population
- Children and adolescents with lupus nephritis (LN), pediatric nephrology clinic of a referral hospital in south India
- Participants
- 40 vs 40
- Exposure
- Children with LN >1 year disease duration vs healthy controls
- LNn = 40
- Healthy controlsn = 40reference
- Outcome
- Cardiovascular assessments (FMD, carotid intima medial thickness (cIMT), echocardiography)
Methodological detailsanalytical, single-centre, age and sex-matched healthy controls
- Analytical
- Single-centre
- Age and sex-matched healthy controls
Main finding
As reported in the abstract
Concentric LVH in LN cases
6
15%
Biplane ejection fraction ≤55% in LN cases
4
10%
Observational data: associations, not effects.
Further findings
Mean resting brachial artery diameter
p 0.010
A-wave velocity
p 0.003
Medial a' velocity
p 0.030
Pulmonary venous atrial reversal duration
p 0.001
Pulmonary venous A-wave duration
p 0.023
LV mass
P < 0.001
| Outcome | Cases | Controls | P value |
|---|---|---|---|
| Proportionate change in FMDMedian | 13.84% (IQR 8.17%–20.31%) | 14.49% (IQR 12.21%–17.24%) | p 0.413 |
| Proportionate change in FMD <10% | 35% | 10% | p 0.007 |
| E/A ratioMean | 1.56 (SD 0.49) | 1.80 (SD 0.44) | p 0.030 |
| GLSMean, % | −21.59 (SD 3.06) | −22.95 (SD 2.38) | p 0.030 |
Mean resting brachial artery diameter
- Lower in cases than age and sex-matched healthy-controls
Proportionate change in flow-mediated dilatation (FMD)
- Comparable
Original publication
Evaluation of cardiovascular morbidities in children and adolescents with lupus nephritis from south India: A cross-sectional analytical study. Lupus. Published 14 March 2026. doi:10.
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