Catching up with calcinosis: analysis of clinical characteristics, myositis-specific autoantibodies, and response to therapy in juvenile dermatomyositis
Authors' conclusion
Calcinosis in JDM is associated with NXP2 autoantibody positivity and delayed diagnosis; however, severity correlates with early disease onset and specific MSA patterns.
Study context
- Population
- Juvenile dermatomyositis (JDM) patients (modified Bohan and Peter criteria), tertiary-care referral centre in India, 1992–2024
- Participants
- 157 patients
- Exposure
- JDM with calcinosis vs JDM without calcinosis
- Calcinosisn = 44
- Outcome
- Prevalence of calcinosis
Methodological detailssingle-centre, tertiary-care referral centre
- Single-centre
- Tertiary-care referral centre
Main finding
As reported in the abstract
Calcinosis
28%
44
Observational data: associations, not effects.
Further findings
Lipodystrophy
Lipodystrophy
- Lipodystrophy significantly associated with presence of calcinosis
Diagnostic delay and NXP2 positivity in calcinosis
- Diagnostic delay in calcinosis
- 12 months
- NXP2-positive in calcinosis
- 41%
Calcinosis severity
- Severe calcinosis linked to early age of onset
- TIF1-gamma positive: predominantly superficial calcinosis around large joints with skin ulceration
- NXP2 positive: extensive and severe calcinosis
Calcinosis alone without clinically obvious skin or muscle disease
- Children presenting with calcinosis alone
- 4
- Of these, NXP2-positive
- 2
Calcinosis course
- Improved
- 39%
- Static/progressive
- 61%
- Drugs targeting calcium/phosphorus metabolism linked to improvement over time
Original publication
Catching up with calcinosis: analysis of clinical characteristics, myositis-specific autoantibodies, and response to therapy in juvenile dermatomyositis. Clin Exp Rheumatol. Published 7 February 2026. doi:10.
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