Bone mineral density in egyptian children with juvenile idiopathic arthritis: possible correlation to serum RANKL / osteoprotegerin (OPG) ratio and OPG gene polymorphisms
Authors' conclusion
Egyptian children with JIA have decreased BMD. rs2073617 TT genotype and T allele, RANKL/OPG ratio are possible determinants of reduced BMD in JIA.
Study context
- Population
- Egyptian children with juvenile idiopathic arthritis (JIA) (mean age 12.05 ± 3.2 years; 38 females; systemic-onset JIA most frequent, 38%) and matched healthy controls
- Participants
- 60 vs 100
- Comparison
- JIA children vs matched healthy controls; within JIA, bone mineral density (BMD) z-score below vs above −2
- JIAn = 60
- Controlsn = 100reference
- Outcome
- BMD (lumbar DEXA z-score) and its association with OPG gene polymorphisms (rs2073617, rs3134069), serum RANKL, OPG and RANKL/OPG ratio
Methodological detailsmatched healthy controls
- Matched healthy controls
Main finding
As reported in the abstract
BMD z-score below −2 (lumbar DEXA) in JIA patients
Patients with BMD z-score below −2
31%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| OPG polymorphisms and serum markers, JIA vs controlsJIA vs Controls | P = < 0.001 |
| OPG polymorphisms and serum markers, JIA vs controlsJIA vs Controls | 0.03 |
- OPG polymorphisms and serum markers, JIA vs controls — Genotype and allele frequencies of the 2 polymorphisms did not differ between patients and controls
- p > 0.05 for all
Original publication
Bone mineral density in egyptian children with juvenile idiopathic arthritis: possible correlation to serum RANKL / osteoprotegerin (OPG) ratio and OPG gene polymorphisms. Pediatr Rheumatol Online J. Published 16 June 2023. doi:10.
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