Association of FKBP4 gene polymorphisms with glucocorticoid efficacy in pediatric systemic lupus erythematosus
Authors' conclusion
FKBP4 polymorphisms may modulate the therapeutic response in pSLE, potentially influencing GC receptor function. rs11833878 was linked to improvements in PLT, SLEDAI-2K score, and proteinuria, whereas rs41456246 was associated with WBC, GC dosage, and PLT recovery.
Study context
- Population
- Pediatric SLE patients and age- and sex-matched healthy controls, recruited October 2022–June 2024
- Participants
- 45 vs 45
- Comparison
- Genotypes of FKBP4 single nucleotide polymorphisms (SNPs) (rs11833878, rs1981655, rs41456246) in pediatric systemic lupus erythematosus (pSLE) vs healthy controls; association with glucocorticoid (GC) treatment efficacy
- pSLEn = 45
- Healthy controlsn = 45reference
- Outcome
- Association of FKBP4 SNP genotypes with GC treatment efficacy (SLEDAI-2K, laboratory parameters, GC dosage)
- Follow-up
- Baseline, 3 and 6 months
Methodological detailsage- and sex-matched healthy controls, Genotyping using the imLDR® kit
- Age- and sex-matched healthy controls
- Genotyping using the imLDR® kit
Main finding
As reported in the abstract
Association of FKBP4 genotypes with clinical indicators
- rs11833878: baseline platelet (PLT) count
- P = 0.037
- rs11833878: PLT improvement at 3 months
- P = 0.016
- rs11833878: SLEDAI-2K reduction, baseline to 6 months
- P = 0.019
- rs11833878: PLT change, baseline to 6 months
- P = 0.035
- rs11833878: 24-hour urinary protein reduction, 3 to 6 months
- P = 0.047
- rs41456246: baseline white blood cell (WBC) count
- P = 0.011
- rs41456246: GC dosage at 3 months
- P = 0.029
- rs41456246: magnitude of GC tapering, baseline to 6 months
- P = 0.021
- rs41456246: PLT improvement, baseline to 6 months
- P = 0.034
- rs41456246: extent of GC tapering, 3 to 6 months
- P = 0.011
Original publication
Association of FKBP4 gene polymorphisms with glucocorticoid efficacy in pediatric systemic lupus erythematosus. Pediatr Rheumatol Online J. Published 29 May 2026. doi:10.
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