Real-world application of the pediatric Glucocorticoid Toxicity Index in childhood-onset lupus
Authors' conclusion
Patients with pSLE experience a high burden of GC toxicity, particularly related to blood pressure, BMI, sleep, and growth.
Study context
- Population
- Patients with pSLE treated with glucocorticoid (GCs) at two pediatric centers (1999–2023)88 with nephritis
- Participants
- 126 patients
- Outcome
- Feasibility and construct validity of retrospective pGTI scoring; risk factors for cumulative toxicity (CWS)
Methodological detailstwo pediatric centers, mixed effects linear regression
- Two pediatric centers
- Mixed effects linear regression
Main finding
As reported in the abstract
GC toxicity by modified pGTI domain
- Toxicity in Blood Pressure domain
- 47 %
- Mood disturbance
- 25 %
- Increased body mass index (BMI)
- 21 %
- Striae
- 21 %
- Sleep disturbance
- 21 %
- Decreased growth velocity
- 18 %
- Correlation between cumulative GC dose and Cumulative Worsening Score (CWS) (rho)
- 0.3; p < 0.01
Observational data: associations, not effects.
Original publication
Real-world application of the pediatric Glucocorticoid Toxicity Index in childhood-onset lupus. Semin Arthritis Rheum. Published 15 July 2024. doi:10.
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