Disease relapse rate in children with autoimmune rheumatic diseases after COVID-19 infection and vaccination
Authors' conclusion
There is a trend towards a higher relapse rate in pARD after infection compared to vaccination and connection between the severity of COVID-19 and vaccination status is plausible. Our results were, however, not statistically significant.
Study context
- Population
- Paediatric patients with autoimmune rheumatic diseases (pARD), March 2020 to April 2022
- Participants
- 92 vs 47
- Exposure
- Relapse of autoimmune rheumatic disease (ARD) after COVID-19 infection vs after COVID-19 vaccination
- Infectionn = 92
- Vaccinationn = 47reference
- Outcome
- Relapse of ARD, defined as a worsening of the ARD within 8 weeks after infection or vaccination
- Follow-up
- 8 weeks
Main finding
As reported in the abstract
Relapse of ARD
P = 0.76
Observational data: associations, not effects.
Further findings
Clinical presentation of SARS-CoV-2 infections (103 infections in 92 pARD)
- Asymptomatic
- 14%
- Mild
- 67%
- Moderate
- 18%
- Required hospitalization
- 1%
Relapse rate by clinical presentation of infection
- No statistically significant difference (p = 0.25)
Severity of COVID-19, vaccinated vs unvaccinated pARD
- No statistically significant difference (p = 0.31)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Disease relapse rate in children with autoimmune rheumatic diseases after COVID-19 infection and vaccination. Pediatr Rheumatol Online J. Published 19 May 2023. doi:10.
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