B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children
Authors' conclusion
We demonstrate an epigenetically distinct profile in pSLE B cells when compared with healthy children and adults with lupus, indicating that pSLE B cells are predisposed for disease onset/development.
Study context
- Population
- Treatment-naive paediatric SLE patients with at least moderate disease severity and healthy children; B cells
- Participants
- 10 vs 5
- Comparison
- Treatment-naive paediatric SLE (pSLE) vs healthy children
- pSLEn = 10
- Healthy childrenn = 5reference
- Outcome
- Differences in epigenetically regulated chromatin architecture (open chromatin) in pSLE vs healthy children
Methodological detailsAssay for transposase-accessible chromatin with sequencing (ATACseq), treatment-naive
- ATACseq
- Treatment-naive
Main finding
As reported in the abstract
Differentially accessible regions (DAR) in pSLE B cells
- Differentially accessible regions (DAR) unique to pSLE B cells
- 30 139
- DAR more accessible in pSLE than healthy children
- 64.3%
- Many DAR in distal, intergenic regions, enriched for enhancer histone marks
- p=0.027
- DAR within or near known SLE haplotypes
- 65.2%
Original publication
B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children. Lupus Sci Med. Published 18 May 2023. doi:10.
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