Clinical characteristics of early-onset paediatric systemic lupus erythematosus in a single centre in China
Authors' conclusion
Early-onset (<5 years) pSLE is characterized by an insidious onset, typical immunological patterns, and the involvement of multiple organs.
Study context
- Population
- Children aged <5 years with SLE (early-onset pSLE), single centre in China, January 2012 to December 20216 males · 13 females
- Participants
- 19 children
- Outcome
- Clinical characteristics of early-onset paediatric SLE (eo-pSLE)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Mean age at onset (years)
- 3.73
- Median diagnostic delay (months); longer in male patients (P = 0.02)
- 9
- SLE-relevant family history (patients)
- 4
- Renal involvement
- 94.74%
- Mucocutaneous involvement
- 94.74%
- Haematological involvement
- 89.47%
- Respiratory involvement
- 89.47%
- Digestive involvement
- 84.21%
- Cardiovascular involvement
- 57.89%
- Neuropsychiatric involvement
- 52.63%
Observational data: associations, not effects.
Further findings
Genetic testing (DNA sequencing in 11 of 19 patients)
- Patients with SLE-associated gene mutations (of 11 sequenced)
- 9
- SLE-associated gene mutations identified: TREX1, PIK3CD, LRBA, KRAS, STAT4, C3, ITGAM, CYBB, TLR5, RIPK1, BACH2, CFHR5, SYK
- 13
- Male patient with 47, XXY chromosomal abnormality
- 1
Original publication
Clinical characteristics of early-onset paediatric systemic lupus erythematosus in a single centre in China. Rheumatology (Oxford). Published 22 February 2023. doi:10.
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