Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain
Authors' conclusion
Disease activity trajectories in a pSLE cohort were predicted by baseline SLEDAI 2K and insurance. Only half of the patients achieved LLDAS during the 2-year study period, which was predicted by baseline characteristics including pain interference.
Study context
- Population
- Participants with pSLE diagnosed within 12 months of baseline visit, Childhood Arthritis and Rheumatology Research Alliance Registry269 for lupus low disease activity state (LLDAS) analyses
- Participants
- 553 participants
- Exposure
- T1 vs T2 vs T3
- Outcome
- Disease activity trajectories measured by SLEDAI 2K
- Follow-up
- 2 years
Methodological detailslatent trajectory analysis, multinomial generalised logistic regression
- Latent trajectory analysis
- Multinomial generalised logistic regression
Main finding
As reported in the abstract
SLEDAI 2K trajectories
- Three trajectories: (T1) low and stable, (T2) high and decreasing, (T3) intermediate and stable
- Baseline SLEDAI 2K score and insurance type significantly associated with trajectories
Observational data: associations, not effects.
Further findings
LLDAS achieved at least once · 24 months
- Patients achieving LLDAS at least once in 24 months
- 51% (136/269)
- Patients achieving LLDAS at first assessment
- 17% (47/269)
Predictors of LLDAS attainment
- LLDAS at both time points predicted by lower pain interference scores
- LLDAS over 24 months also associated with baseline ACR classification criteria, RTX use at baseline and highest completed parent/guardian education
Original publication
Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain. Lupus Sci Med. Published 14 August 2025. doi:10.
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