Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry
Authors' conclusion
Five trajectories of JIA disease activity, and associated baseline variables, were identified.
Study context
- Population
- JIA patients in the CARRA Registry enrolled within 3 months of diagnosis (15 June 2015 to 6 December 2017) with at least two cJADAS10 scores and 24 months of follow-up
- Participants
- 746 patients
- Exposure
- High, Rapidly Decreasing (HRD) vs High, Slowly Decreasing (HSD) vs High, Increasing (HI) vs Moderate, Persistent (MP) vs MD
- HRDn = 199reference
- HSDn = 154
- HIn = 39
- MPn = 218
- MDn = 136
- Outcome
- Trajectories of cJADAS10 and associated baseline characteristics
- Follow-up
- 2 years
Methodological detailslatent growth curve models, 2-year trajectories
- Latent growth curve models
- 2-year trajectories
Main finding
As reported in the abstract
cJADAS10 trajectory groups
Observational data: associations, not effects.
Further findings
Baseline characteristics associated with trajectories
- HSD vs HRD: more likely older, lower PGA, normal inflammatory markers, longer time to first biologic, and taken systemic steroids
- HI vs HRD: more likely ANA negative, longer time to first biologic, less likely taking a csDMARD
- MP vs MD: more likely older, lower household income, longer time to diagnosis, markers of higher disease activity
Original publication
Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry. Rheumatology (Oxford). Published 15 June 2022. doi:10.
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