Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers
Authors' conclusion
These findings suggest that both CM B cells lacking the CXCR5 follicular marker and CXCR5- Th2 cells represent potential biomarkers of DA in juvenile DM and may contribute to its pathogenesis.
Study context
- Population
- Patients with JDM and healthy controls
- Participants
- 123 vs 53
- Exposure
- Juvenile dermatomyositis (DM) patients vs healthy controls
- Juvenile DMn = 123
- Healthy controlsn = 53reference
- Outcome
- Blood markers of JDM disease activity
Methodological detailscase-control comparison, flow cytometry, whole blood transcriptional profiling
- Case-control comparison
- Flow cytometry
- Whole blood transcriptional profiling
Main finding
As reported in the abstract
- CXCR5low/- conventional memory (CD27+IgD-) B cells significantly increased in frequency and absolute numbers in 2 independent JDM cohorts vs healthy controls
- Frequency of CD4+ Th2 memory cells (CD45RA-CXCR5-CCR6-CXCR3-) increased in JDM, especially <1 year from diagnosis
- Frequency of CXCR5low/- CM B cells correlated with serum aldolase and a blood interferon-stimulated gene transcriptional signature
- Frequency and absolute numbers of CXCR5low/- CM B cells correlated with clinical and laboratory measures of muscle disease activity (MMT-8, Childhood Myositis Assessment Scale (CMAS), aldolase, LDH)
Observational data: associations, not effects.
Original publication
Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers. Arthritis Rheumatol. Published 18 May 2023. doi:10.
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