Lupus & antiphospholipid syndrome
Transforming growth factor beta 1 is associated with subclinical carotid atherosclerosis in patients with systemic lupus erythematosus
Main finding · Presence of carotid plaque per serum TGF-β1, adjusted for demographics, lipid profile, insulin resistance and SLEDAIResult — go to the resultOdds ratio 1.14 95% CI 1.003–1.30Authors' conclusion
TGF-β1 serum levels are positively and independently associated with the presence of subclinical atherosclerosis disease in patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE)
- Participants
- 284 patients
- Outcome
- Relationship of serum TGF-β1 with subclinical carotid atherosclerosis (carotid US)
Methodological detailsmultivariable linear and logistic regression
- Multivariable linear and logistic regression
Main finding
As reported in the abstract
Presence of carotid plaque per serum TGF-β1, adjusted for demographics, lipid profile, insulin resistance and SLEDAI
Odds ratio
1.14
95% CI 1.003–1.30
P = 0.045
TGF-β1
OR 1.14 (95% CI 1.003–1.30); P = 0.045
Per serum TGF-β1, as printed
Observational data: associations, not effects.
Further findings
Lipid profile
- TGF-β1 positively and significantly associated with higher LDL:HDL cholesterol ratio and atherogenic index
- TGF-β1 associated with significantly lower HDL cholesterol and apolipoprotein A1
Original publication
Transforming growth factor beta 1 is associated with subclinical carotid atherosclerosis in patients with systemic lupus erythematosus. Arthritis Res Ther. Published 17 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →