Lupus & antiphospholipid syndrome
QRISK3 and SCORE2 are equally reliable predictors of carotid plaques in patients with systemic lupus erythematosus
Authors' conclusion
QRISK3 and SCORE2 are equally reliable predictors of carotid plaques in SLE patients. The combination of both calculators offers significantly better discrimination than QRISK3 alone but shows no significant difference when compared with SCORE2 alone.
Study context
- Population
- SLE patients evaluated for subclinical atherosclerosis with carotid US
- Participants
- 365 patients
- Exposure
- QRISK3 vs SCORE2 for prediction of carotid plaques
- Outcome
- Discriminatory capacity (AUC) for presence of carotid plaques
Methodological detailslogistic regression, AUC analysis
- Logistic regression
- AUC analysis
Main finding
As reported in the abstract
Carotid plaque, AUC
| Group | AUC |
|---|---|
| QRISK3 | 0.770 (95% CI 0.720, 0.821) |
| SCORE2 | 0.800 (95% CI 0.753, 0.843) |
AUC
QRISK30.770 (95% CI 0.720, 0.821)
SCORE20.800 (95% CI 0.753, 0.843)
- QRISK3 vs SCORE2: P = 0.070 — similar, no statistically significant difference
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Carotid plaque, discrimination of combined calculatorsQRISK3 + SCORE2 vs QRISK3 · combination significantly greater | P = 0.034 |
| Carotid plaque, discrimination of combined calculatorsQRISK3 + SCORE2 vs SCORE2 · did not differ | P = 0.71 |
Original publication
QRISK3 and SCORE2 are equally reliable predictors of carotid plaques in patients with systemic lupus erythematosus. Rheumatology (Oxford). Published 4 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →