Lupus & antiphospholipid syndrome
Generic and disease-adapted cardiovascular risk scores as predictors of atherosclerosis progression in SLE
Study context
- Population
- Patients with SLE without history of cardiovascular events or diabetes mellitus (90% female, mean age 44.4±11.7 years)
- Participants
- 124 patients
- Comparison
- Five generic vs three SLE-adapted cardiovascular risk (CVR) scores for predicting atherosclerosis progression
- Outcome
- Atherosclerosis progression (new atherosclerotic plaque development), predicted by baseline CVR scores
- Follow-up
- 3 years
Methodological details3-year carotid and femoral US follow-up, binary logistic regression
- 3-year carotid and femoral US follow-up
- Binary logistic regression
Performance
As reported in the abstract
Prediction of plaque progression · mean 39.7±3.8 months
| Test or model | Brier Score | AUROC | Matthews correlation coefficient (MCC) |
|---|---|---|---|
| Modified Framingham Risk Score (mFRS) | 0.14 | 0.80 | 0.22 |
| QRISK3 | 0.16 | 0.75 | 0.25 |
Brier Score
Modified Framingham Risk Score (mFRS)0.14
QRISK30.16
AUROC
Modified Framingham Risk Score (mFRS)0.80
QRISK30.75
Matthews correlation coefficient (MCC)
Modified Framingham Risk Score (mFRS)0.22
QRISK30.25
- Patients developing new atherosclerotic plaques
- 26 (21%)
Further findings
Determinants of plaque progression (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| QRISK3Independently associated with plaque progression | 4.24 (1.30–13.78) | P = 0.016 | |
| AgeIndependently associated with plaque progression | 1.13 (1.06–1.21) | P < 0.001 | |
| Cumulative GC doseIndependently associated with plaque progression | 1.04 (1.01–1.07) | P = 0.010 | |
| aPLIndependently associated with plaque progression | 3.66 (1.24–10.80) | P = 0.019 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Generic and disease-adapted cardiovascular risk scores as predictors of atherosclerosis progression in SLE. Lupus Sci Med. Published 3 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →