Lupus & antiphospholipid syndrome
Effect of Systemic Lupus Erythematosus and Immunosuppressive Agents on COVID‐19 Vaccination Antibody Response
Authors' conclusion
SLE patients, regardless of background immunosuppressive therapy, had lower vaccine IgG levels than health care workers. Mycophenolate, tacrolimus, and belimumab significantly reduced IgG response to vaccination. Holding mycophenolate for 1 week improved vaccine efficacy, providing clinical benefit on vaccine response without leading to clinical flares.
Study context
- Population
- Hopkins Lupus Cohort systemic lupus erythematosus (SLE) patients after COVID-19 vaccination334 SLE patients
- Exposure
- SLE patients vs health care workers
- Outcome
- SARS-CoV-2 antibody IgG levels after vaccination over time; effect of immunosuppressive medications on postvaccination IgG levels in SLE
Methodological detailscomparison cohort of health care workers, 365 observations from 334 SLE patients; 2,235 observations from 1,887 health care workers
- Comparison cohort of health care workers
- 365 observations from 334 SLE patients; 2,235 observations from 1,887 health care workers
Main finding
As reported in the abstract
Postvaccination IgG levels
- SLE patients taking immunosuppressive medications had lower vaccine IgG levels than SLE patients not taking them
- Both SLE groups had lower levels than health care workers
- In multiple variable models, mycophenolate mofetil, tacrolimus and belimumab all significantly reduced antibody response to vaccination
Observational data: associations, not effects.
Further findings
Holding mycophenolate for 1 week after vaccination
- Increased postvaccine IgG levels significantly without leading to clinical flares
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Systemic Lupus Erythematosus and Immunosuppressive Agents on COVID‐19 Vaccination Antibody Response. Arthritis Care Res (Hoboken). Published 1 March 2023. doi:10.
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