Lupus & antiphospholipid syndrome
Clinical associations of cognitive dysfunction in systemic lupus erythematosus
Authors' conclusion
In SLE, cognitive dysfunction was positively associated with organ damage, but not associated with disease activity, and serological activity and high IFN signature were negatively associated. Cognitive dysfunction was poorly captured by clinicians.
Study context
- Population
- Patients with SLE (median age 45; disease duration 15 years)
- Participants
- 89 patients
- Outcome
- Two binary definitions of cognitive dysfunction and seven individual cognitive domain scores, by conventional neuropsychological test battery
Methodological detailsregression analyses, normative values from demographically matched healthy subjects
- Regression analyses
- Normative values from demographically matched healthy subjects
Main finding
As reported in the abstract
Associations of clinical parameters with cognitive dysfunction
Organ damage associated with severe cognitive dysfunction (OR, CI)
OR 1.49, CI 1.01-2.22
Observational data: associations, not effects.
Further findings
Patients with cognitive dysfunction on testing recognised by clinicians on SDI score
- Recognised by clinicians
- 8%
Original publication
Clinical associations of cognitive dysfunction in systemic lupus erythematosus. Lupus Sci Med. Published 28 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →