Lupus & antiphospholipid syndrome
Cognitive dysfunction in systemic lupus erythematosus: A pilot study on the role of serum neuron-specific enolase levels
Authors' conclusion
This study demonstrates a significant association between neuronal injury, as indicated by elevated serum neuron-specific enolase (NSE) levels, and cognitive impairment in SLE patients, with a particular impact on executive function.
Study context
- Population
- SLE patients aged 18–55 years meeting the EULAR/ACR 2019 criteria, Hasan Sadikin General Hospital, January to August 2024
- Participants
- 81 patients
- Exposure
- SLE with cognitive dysfunction vs normal cognition; serum neuron-specific enolase (NSE) vs MoCA-Ina scores
- Outcome
- Association between serum NSE and MoCA-Ina scores (Spearman's correlation)
Methodological detailspilot study, single-centre
- Pilot study
- Single-centre
Main finding
As reported in the abstract
Correlation of serum NSE with MoCA-Ina scores
Serum NSE vs MoCA-Ina total score, r
r = −0.225
p = .022
Serum NSE vs executive function, r
r = −0.204
p = .034
Observational data: associations, not effects.
Further findings
Median serum NSE
Prevalence of cognitive dysfunction (MoCA-Ina <26)
- Cognitive dysfunction
- 38.3%
Factors associated with cognitive dysfunction
- Cognitive dysfunction associated with longer disease duration and a history of seizures
Original publication
Cognitive dysfunction in systemic lupus erythematosus: A pilot study on the role of serum neuron-specific enolase levels. Lupus. Published 9 August 2025. doi:10.
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