Lupus & antiphospholipid syndrome
Comparison of cognitive performance measures in individuals with systemic lupus erythematosus
Authors' conclusion
The TMTB, CLOX and NIH Fluid Cognition Battery each provided unique and potentially important information about cognitive performance in our SLE cohort.
Study context
- Population
- Population-based cohort of individuals with validated SLE (mean age 46 years; 92% female; 82% black)
- Participants
- 423 / 435 / 199
- Exposure
- Trail Making Test B (TMTB) vs CLOX vs National Institutes of Health (NIH) Toolbox Fluid Cognition Battery
- TMTBn = 423
- CLOXn = 435
- NIH Toolbox Fluid Cognition Batteryn = 199
- Outcome
- Cognitive performance and potential impairment across multiple measures of cognition
Methodological detailspopulation-based cohort, single study visit, Single study visit, October 2019-May 2022
- Population-based cohort
- Single study visit
- Single study visit, October 2019-May 2022
Main finding
As reported in the abstract
TMTB
96
median · IQR 76–130 · s
CLOX1
12
median · IQR 10–13
CLOX2
14
median · IQR 13–15
Fluid cognition
87.2
mean · SD 15.6 · standard score
- Potentially impaired by TMTB test
- 65%
- Potentially impaired by CLOX task
- 55%
- Potentially impaired by NIH Toolbox Fluid Cognition Battery
- 28%
- Correlation of TMTB time and fluid cognition score (most highly intercorrelated measures)
- ρ=−0.53, p<0.001
- Impairment by only one of TMTB and CLOX
- 58%
- Impairment in fluid cognition only
- 2%
Observational data: associations, not effects.
Original publication
Comparison of cognitive performance measures in individuals with systemic lupus erythematosus. Lupus Sci Med. Published 16 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →