Predictors of damage accrual and its impact on health-related quality of life of thrombotic antiphospholipid syndrome: Independent validation of the damage index for antiphospholipid syndrome (DIAPS)

Gaspar, P; Fernandes, ASM; Abrantes, AM; Parreira, I; Silva, I; Silva, RC; Nobre, MB; Martins, JR; Mota, C

doi:10.1177/09612033241246360

Lupus & antiphospholipid syndrome

Predictors of damage accrual and its impact on health-related quality of life of thrombotic antiphospholipid syndrome: Independent validation of the damage index for antiphospholipid syndrome (DIAPS)

LupusPublished 14 Apr 2024Cross-sectional study

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Authors' conclusion

This external validation of DIAPS reinforces the ability of the score to correlate with HR-QoL while also highlighting risk factors for HR-QoL impairment other than damage accrual.

Study context

Population: Thrombotic antiphospholipid syndrome (APS) patients (Sydney criteria) attending a Portuguese tertiary centreprimary APS, 75.9%
Participants: 108 patients

Outcome: Prevalence of damage (DIAPS≥1) and its impact on HR-QoL (EQ-5D-3L, EQ-5D-5L, Visual Analogue Scale (VAS))

Methodological detailssingle-centre (Portuguese tertiary centre), phone questionnaire, univariate and multivariate logistic regression

Single-centre (Portuguese tertiary centre)
Phone questionnaire
Univariate and multivariate logistic regression

Main finding

As reported in the abstract

Damage (DIAPS≥1)

Damage (DIAPS≥1) prevalence

48.2%

DIAPS, mean ± SD

3.08 ± 1.83

Neuropsychiatric domain most affected

24.2%

Peripheral vascular domain

20.3%

Observational data: associations, not effects.

Further findings

Pain/discomfort, anxiety/depression and usual activities domains most frequently impaired in both scales
DIAPS domains correlated similarly with EQ-5D-3L and 5L individual domains
Female sex, medical disorders, secondary APS and arterial presenting thrombosis increased risk of health-related quality of life (HR-QoL) impairment
Total DIAPS associated with higher odds of mobility, self-care and pain/discomfort impairment in both scales but lost independent risk in multivariable analysis

Original publication

Predictors of damage accrual and its impact on health-related quality of life of thrombotic antiphospholipid syndrome: Independent validation of the damage index for antiphospholipid syndrome (DIAPS). Lupus. Published 14 April 2024. doi:10.1177/09612033241246360

Read the original article ↗

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