Lupus & antiphospholipid syndrome
High Prevalence but Low Impact of Cognitive Dysfunction on Quality of Life in Patients With Lupus and Neuropsychiatric Symptoms
Authors' conclusion
Objective cognitive impairment is common in SLE patients with NP symptoms, but may have a limited influence on HRQoL.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and neuropsychiatric (NP) symptoms referred to the Leiden NPSLE clinic (2007–2019)169 with follow-up visit
- Participants
- 357 patients
- Exposure
- Cognition vs NPSLE phenotype and cognition vs health-related-quality of life (HRQoL)
- Outcome
- Prevalence of cognitive impairment and its impact on HRQoL (SF-36 mental and physical component scores)
Methodological detailsmultidisciplinary evaluation, multiple regression analyses and linear mixed models corrected for confounding
- Multidisciplinary evaluation
- Multiple regression analyses and linear mixed models corrected for confounding
Main finding
As reported in the abstract
Cognitive impairment prevalence
Impairment in global cognitive function
8%
Impairment in all other cognitive domains
±50%
Observational data: associations, not effects.
Further findings
Association between cognition and HRQoL
- Weak association, cross-sectionally and longitudinally
- 1 SD lower cognitive domain scores associated with at most one-fifth SD lower HRQoL
Original publication
High Prevalence but Low Impact of Cognitive Dysfunction on Quality of Life in Patients With Lupus and Neuropsychiatric Symptoms. Arthritis Care Res (Hoboken). Published 12 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →