Lupus & antiphospholipid syndrome
Systemic lupus erythematosus incidence and prevalence in a large population-based study in northeastern Italy
Authors' conclusion
Over the last decade, SLE prevalence has increased, while incidence has stably declined.
Study context
- Population
- Residents of Veneto Region, northeastern Italy (4.9 million people), 2012–201,092 incident cases
- Participants
- 4,283 residents
- Exposure
- Females vs Males
- Outcome
- Incidence and prevalence of SLE
- Follow-up
- 2012-20
Methodological detailsadministrative health database, standardized rates by age and sex
- Administrative health database
- Standardized rates by age and sex
Main finding
As reported in the abstract
SLE standardized point prevalence and incidence
- Standardized point prevalence at start of study period, per 100 000 residents
- 63.5 (95% CI 61.2, 65.8)
- Standardized point prevalence at end of study period, per 100 000 residents
- 70.6 (95% CI 68.3, 73.0)
- Annual increment in prevalence (P < 0.0001)
- 1.14%
- SLE incidence per 100 000 person-years
- 2.8 (95% CI 2.6, 2.9)
- Annual decline in incidence (P < 0.0001)
- 7.3%
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | P value | |
|---|---|---|---|
| SLE incidence, femalevs male · 2013-2020Female-to-male incidence rate ratio | 5.00 (4.25–5.87) | P < 0.0001 | |
| 0.20.5125Incidence rate ratio (log scale) |
Age at diagnosis
SLE incidence, female vs male · 2013-2020
- Peak incidence among women aged 30-39 years
Age at diagnosis
- Women significantly younger than men at diagnosis
Highest SLE prevalence
- Highest prevalence observed in females aged 60-69 years
Original publication
Systemic lupus erythematosus incidence and prevalence in a large population-based study in northeastern Italy. Rheumatology (Oxford). Published 10 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →