Lupus & antiphospholipid syndrome
Reduced circulating Tregs and positive perinuclear antineutrophil cytoplasmic antibody (pANCA) were robustly associated with the occurrence of antiphospholipid syndrome in patients with systemic lupus erythematosus
Authors' conclusion
The present study revealed a robust association between APS secondary to SLE and reduced Tregs and positive pANCA, which provides essential information regarding the diagnosis and therapeutic possibilities of APS secondary to SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) with or without antiphospholipid syndrome (APS)
- Exposure
- SLE with APS vs SLE without APS
- Outcome
- Independent risk factors for SLE secondary APS
Main finding
As reported in the abstract
- Reduced Tregs and positive pANCA were independent risk factors for SLE secondary APS
Observational data: associations, not effects.
Further findings
Clinical features, Systemic lupus erythematosus with APS (SLE-APS) vs without APS
- SLE-APS had elevated SLEDAI scores, hospitalization costs and time, and frequencies of CNS symptoms and spontaneous abortion
Antibody positivity, SLE-APS vs None-APS
- SLE-APS had higher positive aCL, anti-β2 glycoprotein 1 antibodies and pANCA
Circulating lymphocyte subsets vs healthy controls (HCs)
- Altered to some extent in all patients, especially SLE-APS
Original publication
Reduced circulating Tregs and positive pANCA were robustly associated with the occurrence of antiphospholipid syndrome in patients with systemic lupus erythematosus. Lupus. Published 13 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →