Lupus & antiphospholipid syndrome

Sex and Racial Differences in Systemic Lupus Erythematosus Among US Adults in the All of Us Research Program

Arthritis Care Res (Hoboken)Published Cross-sectional study

Authors' conclusion

Our study demonstrated major clinical and health literacy differences in men and women with SLE. Socioeconomic factors were significant barriers to health care in both sexes.

Study context

Population
Participants with systemic lupus erythematosus (SLE) in the All of Us Research Program, a US cohort (enrollment May 2018 to June 2022)126 (9%) male
Participants
1,462 participants
Exposure
Men vs women with SLE
  • Menn = 126
Outcome
Characteristics of men vs women with SLE
Methodological detailslinked electronic health record (EHR) data and participant survey
  • Linked EHR data and participant survey

Main finding

As reported in the abstract

  • Men reported lower educational attainment and less fatigue than women
  • MI significantly more common in men
  • Men had significantly less confidence in completing medical forms than women and a trend toward requiring more help in reading health-related materials

Observational data: associations, not effects.

Further findings

Some reason for delay in care

P = 0.35

Delaying care due to cultural differences between patient and provider, by race (women)

Women of race other than Black or African American or White more often reported delaying care due to cultural differences

Original publication

Sex and Racial Differences in Systemic Lupus Erythematosus Among US Adults in the All of Us Research Program. Arthritis Care Res (Hoboken). Published 12 April 2023. doi:10.1002/acr.25093

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