Lupus & antiphospholipid syndrome
Prevalence of cardiovascular events in a population-based registry of patients with systemic lupus erythematosus
Authors' conclusion
These population-based estimates of CVE in a diverse registry of patients with SLE revealed increased rates among younger male, Hispanic/Latino and non-Hispanic Black patients.
Study context
- Population
- Patients with prevalent systemic lupus erythematosus (SLE) in 2007 aged ≥ 20 years in the Manhattan Lupus Surveillance Program (MLSP)MLSP registry
- Participants
- 1,285 patients
- Exposure
- Patients with SLE in the MLSP vs population-based controls; and by sex, age and race/ethnicity within the registry
- Outcome
- Prevalence of CVE (documented MI or cerebrovascular accident)
Methodological detailspopulation-based registry, comparison with population-based controls (National Health and Nutrition Examination Survey (NHANES), NYC HANES)
- Population-based registry
- Comparison with population-based controls (NHANES, NYC HANES)
Main finding
As reported in the abstract
CVE prevalence
Each group vs Non-Hispanic AsianAdjusted relative risk (95% CI)
Men
1.7(1.2–2.5)
Age > 60
2.5(1.7–3.8)
Hispanic/Latino
3.1(1.4–7.0)
Non-Hispanic Black
3.5(1.6–7.9)
Non-Hispanic, another or multiple racial groups
4.2(1.1–15.8)
- CVE prevalence in MLSP patients with SLE
- 13.9%
Observational data: associations, not effects.
Further findings
| Outcome | PR (95% CI) | |
|---|---|---|
| CVE prevalence, SLE vs age-stratified national estimatesAge 20-49 yearsvs National estimates | 6.4 (6.2–6.5) | |
| CVE prevalence, SLE vs age-stratified national estimatesAge ≥ 50 yearsvs National estimates | 2.2 (2.1–2.2) | |
| CVE PR, SLE patients aged 20-49 (subgroups) vs national estimatesMalevs National estimates | 11.3 (10.5–12.1) | |
| CVE PR, SLE patients aged 20-49 (subgroups) vs national estimatesHispanic/Latinovs National estimates | 10.9 (10.5–11.4) | |
| CVE PR, SLE patients aged 20-49 (subgroups) vs national estimatesNon-Hispanic Blackvs National estimates | 6.2 (6.0–6.4) | |
| 0.050.21520Prevalence ratio (log scale) |
| Outcome | ASPR (95% CI) |
|---|---|
| CVE prevalence, SLE vs national estimates (overall) | 3.1 (3.0–3.1) |
| CVE prevalence, SLE Hispanics/Latinos vs national race/ethnicity-stratified estimatesHighest | 4.3 (4.2–4.4) |
CVE prevalence, SLE vs national estimates (overall)
- Did not differ by sex
CVE prevalence, SLE vs all NYC residents
- CVE also elevated among SLE registry patients compared with all NYC residents
Original publication
Prevalence of cardiovascular events in a population-based registry of patients with systemic lupus erythematosus. Arthritis Res Ther. Published 14 September 2024. doi:10.
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