Lupus & antiphospholipid syndrome
Activation of circulating TFH17 cells associated with activated naive and double negative 2 B cell expansion, and disease activity in systemic lupus erythematosus patients
Authors' conclusion
SLE cTFH cells were found to be polarized toward cTFH1 and cTFH17 cells; activation of these cTFH subsets was significantly associated with disease activity score, aNAV, DN2 B cell expansion, and anti-dsDNA antibody level.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients with inactive or active disease; peripheral blood mononuclear cells studied for cTFH, memory cTFH and B cell subsets
- Exposure
- Active vs inactive SLE
- Outcome
- Frequencies and phenotypes of cTFH cells, memory cTFH and B cell subsets, and their correlations with anti-dsDNA and clinical parameters
Methodological detailsmechanistic, flow cytometric phenotyping of peripheral blood mononuclear cells, correlation analysis
- Mechanistic
- Flow cytometric phenotyping of peripheral blood mononuclear cells
- Correlation analysis
Main finding
As reported in the abstract
- cTFH1 and cTFH17 cells significantly expanded and activated in active SLE
- Expanded cTFH1 cells predominantly central memory (CM); cTFH17 cells largely effector memory (EM)
- Increased frequencies of aNAV and DN2 B cells
- ICOS+ cTFH1, ICOS+ cTFH17 cells and SLEDAI-2K scores correlated
- Positive correlations among ICOS+ cTFH1 cells, aNAV B cells and anti-dsDNA antibodies
- Activation of ICOS+ cTFH17 cells significantly related to expansion of aNAV and DN2 B cells
- CM cells in cTFH1 and cTFH17 subsets correlated with aNAV and DN2 B cell frequencies
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Activation of circulating TFH17 cells associated with activated naive and double negative 2 B cell expansion, and disease activity in systemic lupus erythematosus patients. Arthritis Res Ther. Published 11 September 2024. doi:10.
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