Lupus & antiphospholipid syndrome
Predictors of first hospitalization due to disease activity and infections in systemic lupus erythematosus patients
Authors' conclusion
The first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. Conversely, AM use and achieving remission were associated with a lower risk of hospitalizations.
Study context
- Population
- SLE patients from a Latin American cohort1,200 (89.5%) women
- Participants
- 1,341 patients
- Outcome
- First hospitalization after cohort entry due to lupus disease activity and/or infection
Methodological detailsmultivariable logistic regression, Cox regression, Median age at diagnosis 27 (IQR 20-37) years; median follow-up 27.5 (IQR 4.7-62.2) months
- Multivariable logistic regression
- Cox regression
- Median age at diagnosis 27 (IQR 20-37) years; median follow-up 27.5 (IQR 4.7-62.2) months
Main finding
As reported in the abstract
First hospitalization (any cause), predictors
Hazard ratio (CI)P value
Medium socioeconomic status
2.03(1.27–3.24)
P = 0.0028Low socioeconomic status
2.42(1.55–3.79)
P < 0.0001Serosal involvement
1.32(1.07–1.62)
P = 0.0074Renal involvement
1.50(1.23–1.82)
P < 0.0001Antimalarial usenegative predictor
0.61(0.50–0.74)
P < 0.0001Achieving remissionnegative predictor
0.80(0.65–0.97)
P = 0.0300- Patients hospitalized
- 456 (34.0%)
- Hospitalized for disease activity
- 344 (75.4%)
- Hospitalized for infections
- 85 (18.6%)
- Hospitalized for both
- 27 (5.9%)
Observational data: associations, not effects.
Original publication
Predictors of first hospitalization due to disease activity and infections in systemic lupus erythematosus patients. Lupus. Published 11 September 2024. doi:10.
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