Lupus & antiphospholipid syndrome
Association of gut commensal translocation with autoantibody production in systemic lupus erythematosus
Authors' conclusion
ABC transporters from gut bacteria can serve as cross-reactive antigens that may promote anti-dsDNA antibody production in genetically susceptible mice.
Study context
- Population
- B6SKG lupus model mice (impaired TCR signalling, gut dysbiosis) and blood samples from untreated SLE patients
- Outcome
- Role of translocated gut bacteria in autoantibody production via molecular mimicry
Methodological detailslupus model mice (B6SKG), culture-based bacterial profiling, human blood samples
- Lupus model mice (B6SKG)
- Culture-based bacterial profiling
- Human blood samples
Main finding
As reported in the abstract
- Culture-based bacterial profiling of mesenteric lymph nodes (MLNs): Lactobacillus murinus enriched in B6SKG mice with elevated anti-dsDNA IgG
- Subcutaneous heat-killed L. murinus induced anti-dsDNA IgG production, without altering T- or B-cell subset composition
- Immunoblotting and mass spectrometry identified a peptide ATP-binding cassette (ABC) transporter as a molecular mimicry antigen; cross-reactivity in lupus mice confirmed by serological assays and in vivo immunization
- L. murinus ABC transporter surface epitopes cross-reactive with sera from lupus mice and patients
- R. gnavus ABC transporter had a similar epitope sequence to the L. murinus ABC transporter and reacted with lupus sera
Original publication
Association of gut commensal translocation with autoantibody production in systemic lupus erythematosus. Rheumatology (Oxford). Published 9 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →