Lupus & antiphospholipid syndrome
Characteristics and outcomes of biopsy-proven lupus nephritis in the Eastern Cape province of South Africa
Authors' conclusion
Response rates were similar in this cohort when compared to other contemporary studies. Predictors of poor response were an elevated baseline serum creatinine, a decreased eGFR and an elevated blood pressure at time of the biopsy. Infections were the most common occurring adverse event, although the mortality rate remained low at 2.3%.
Study context
- Population
- Patients with biopsy-proven Lupus Nephritis (LN), kidney biopsy 01 January 2012 to 31 December 2021, Livingstone Tertiary Hospital Renal Unit, Gqeberha, South Africa107 proliferative and/or membranous LN
- Participants
- 131 patients
- Outcome
- Outcomes (complete or partial response to treatment) of biopsy-proven LN and predictors of a poor outcome
Methodological detailssingle-centre, biopsy register
- Single-centre
- Biopsy register
Main finding
As reported in the abstract
Complete or partial response at 6 months
69.6%
Complete or partial response at 18 months
70.3%
Complete or partial response at 30 months
72.6%
Observational data: associations, not effects.
Further findings
Predictors of poor response (at time of biopsy)
- Elevated baseline serum creatinine: OR 2.53 (95% CI 0.99 - 6.52), p = .054
- Decreased eGFR: OR 2.92 (95% CI 0.94 - 9.09), p = .065
- Elevated blood pressure: OR 6.06 (95% CI 1.11 - 33.33), p = .038
Progression to kidney failure
- Patients progressing to kidney failure (KF), n (%)
- 7 (5.3%)
- 27 lost to follow-up
Deaths
- Deaths, n (%)
- 3 (2.3%)
Safety
Infections (most common adverse event)
- Infections in 39 (29.8%) patients
- 50
- Herpes viral infections, % of documented infections
- 12 (24.0%)
Original publication
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