Lupus & antiphospholipid syndrome
Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus
Authors' conclusion
Our findings illustrate the disruption of the gut microbiome and lipid group in SLE patients
Study context
- Population
- SLE patients and controls
- Comparison
- SLE vs controls
- Outcome
- Gut microbiota and plasma lipidome in SLE
Methodological details16S rRNA gene sequencing, PICRUSt functional prediction, LC-MS plasma lipidomics, Spearman's rank correlation
- 16S rRNA gene sequencing
- PICRUSt functional prediction
- LC-MS plasma lipidomics
- Spearman's rank correlation
Main finding
As reported in the abstract
- Obvious abnormalities in lipid metabolism in SLE; sphingolipid and glycerophospholipid metabolism the most significantly dysregulated pathways
- Obvious intestinal flora imbalance in SLE; Becteroides and Lachnoclostridium the most important genera distinguishing SLE from controls
- Some differential plasma metabolites correlated with some differential stool bacteria; most lipid-associated bacteria belonged to Firmicutes, Bacteroidetes, Actinobacteriaceae, Peptostreptococcaceae, Gordonibacter, Romboutsia, etc.
Original publication
Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus. Lupus. Published 13 August 2026. doi:10.
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