Lupus & antiphospholipid syndrome
Alterations of the microbiome across body sites in systemic lupus erythematosus: A systematic review and meta-analysis
Authors' conclusion
This meta-analysis offers a comprehensive perspective on microbiome dysbiosis in SLE patients across diverse body sites and taxa.
Study context
- Population
- Studies comparing systemic lupus erythematosus (SLE) patients and healthy controls; gut, oral, skin and other microbiota
- Comparison
- SLE vs healthy controls
- Outcome
- Alpha diversity, beta diversity and taxa abundance of the microbiome across body sites
Methodological detailsNewcastle-Ottawa Scale quality assessment, standardized mean differences, Literature search across four databases
- Newcastle-Ottawa Scale quality assessment
- Standardized mean differences
- Literature search across four databases
Pooled result
As reported in the abstract
- Reduced alpha diversity and distinct beta diversity in SLE, particularly in the gut microbiota
- Compositional variations in bacteria from the gut and oral cavity
- Results for fungi, viruses and bacteria from other sites inconsistent due to limited studies
Original publication
Alterations of the microbiome across body sites in systemic lupus erythematosus: A systematic review and meta-analysis. Lupus. Published 11 September 2024. doi:10.
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