Lupus & antiphospholipid syndrome
Topological structural characteristics in patients with systemic lupus erythematosus with and without neuropsychiatric symptoms
Authors' conclusion
Structural networks in patients SLE may be altered at both global and local levels, with more pronounced changes observed in NPSLE, notably affecting the default mode and sensorimotor networks.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) with and without neuropsychiatric symptoms and age-matched healthy controls (HCs)50 SLE patients
- Participants
- 21 / 29 / 32
- Exposure
- NPSLE vs non-NPSLE vs age-matched HCs
- non-NPSLEn = 21
- NPSLEn = 29
- HCsn = 32reference
- Outcome
- Topological characteristics of individual structural brain networks (global metrics and local network properties)
Methodological detailsprospective recruitment, age-matched healthy controls, MRI diffusion tensor imaging, support vector classification
- Prospective recruitment
- Age-matched healthy controls
- MRI diffusion tensor imaging
- Support vector classification
Main finding
As reported in the abstract
Structural network topology
- Both non-NPSLE and NPSLE showed significant global and local topological alterations vs HCs
- Changes more pronounced in NPSLE, particularly affecting the default mode and sensorimotor networks
Observational data: associations, not effects.
Further findings
Clinical correlations
- Topological changes correlated with lesion burdens, disease duration and SLICC/ACR DI
- Partial correlation
Differentiation of non-NPSLE vs NPSLE (support vector classification)
- Accuracy
- 87%
Original publication
Topological structural characteristics in patients with systemic lupus erythematosus with and without neuropsychiatric symptoms. Lupus Sci Med. Published 11 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →