Lupus & antiphospholipid syndrome
The Impact of Pregnancy Readiness on Lupus Activity, Maternal Mental Health, and Pregnancy Outcomes
Authors' conclusion
To improve pregnancy outcomes among individuals with SLE, greater focus is needed on improving medical optimization before conception.
Study context
- Population
- Pregnant individuals with systemic lupus erythematosus (SLE) (SLICC criteria) in a prospective registry
- Participants
- 111 individuals
- Exposure
- Medically ready vs not medically ready, and personally ready vs not personally ready for pregnancy
- Outcome
- Provider-reported disease activity, patient-perceived disease activity, mood symptoms, pregnancy-related health behaviors and pregnancy outcomes
Methodological detailsprospective registry, multivariable logistic regression
- Prospective registry
- Multivariable logistic regression
Main finding
As reported in the abstract
- Lack of medical readiness associated with significantly higher rates of active disease and worse pregnancy outcomes, but not with higher patient-perceived disease activity
- Lack of personal readiness associated with significantly higher patient-perceived disease activity
- Medical readiness did not impact depressive symptoms substantially; lack of personal readiness associated with much higher maternal depressive symptoms
Observational data: associations, not effects.
Original publication
The Impact of Pregnancy Readiness on Lupus Activity, Maternal Mental Health, and Pregnancy Outcomes. Arthritis Care Res (Hoboken). Published 8 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →