Lupus & antiphospholipid syndrome
Gut and oral microbiota characterized in systemic lupus erythematosus patients from India: A pilot study
Authors' conclusion
Our findings highlight specific microbiome alterations in SLE patients
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from India and healthy controls
- Comparison
- SLE vs healthy controls
- Outcome
- Peripheral immune cells and gut and salivary microbiota
Methodological detailsmetagenomic shotgun sequencing
- Metagenomic shotgun sequencing
Main finding
As reported in the abstract
- Significant alterations in the proportions of CD4+ and CD8+ T cells in SLE, with an inverse correlation between these subsets
- CD4+ ratio elevated in SLE
- CD4+ T cells strongly correlated with double-negative T cells; CD8+ T cells correlated with NK cells
- Microbiome disruption, particularly Pasteurellaceae and Veillonella, altered in both gut and oral microbiomes of SLE patients
- Dysbiosis in both gut and oral microbiomes of SLE, distinguishing them from healthy controls
Observational data: associations, not effects.
Original publication
Gut and oral microbiota characterized in systemic lupus erythematosus patients from India: A pilot study. Lupus. Published 19 March 2026. doi:10.
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