Lupus & antiphospholipid syndrome
Predictors of severe hemolytic anemia and its impact on major outcomes in systemic lupus erythematosus: Data from a multiethnic Latin American cohort
Authors' conclusion
Severe AIHA occurs during the early course of SLE. Male sex and higher disease activity at diagnosis emerged as independent predictors of a shorter time to severe AIHA occurrence.
Study context
- Population
- SLE patients, multiethnic Latin American cohort
- Participants
- 1,349 patients
- Exposure
- Predictors of time to severe autoimmune hemolytic anemia (AIHA) in SLE
- Outcome
- Time to severe AIHA (hemoglobin ≤7 g/dL) from onset of SLE symptoms; impact on damage and mortality
Methodological detailsmultiethnic Latin American cohort, Cox proportional hazards regression, multivariable analysis, Mean (SD) follow-up 5.4 (3.8) years
- Multiethnic Latin American cohort
- Cox proportional hazards regression
- Multivariable analysis
- Mean (SD) follow-up 5.4 (3.8) years
Main finding
As reported in the abstract
Predictors of shorter time to severe AIHA (multivariable)
Hazard ratio (95% CI)P value
Male sex
2.26(1.02–4.75)
P = 0.044Higher disease activity at diagnosis
1.04(1.01–1.08)
P = 0.025Hematologic SLEDAI descriptor (leukopenia and/or thrombocytopenia)trend toward significance
2.36(0.91–6.13)
P = 0.0772- Developed severe AIHA
- 49 (3.6%)
Observational data: associations, not effects.
Further findings
Time from first clinical manifestation to severe AIHA
- Median, days (IQR 43-450)
- 111
Impact of severe AIHA on damage and mortality
- Severe AIHA contributed neither to damage nor to mortality
Original publication
Predictors of severe hemolytic anemia and its impact on major outcomes in systemic lupus erythematosus: Data from a multiethnic Latin American cohort. Lupus. Published 14 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →