Lupus & antiphospholipid syndrome
Disrupted resting-state brain functional network properties in non-neuropsychiatric systemic lupus erythematosus patients
Authors' conclusion
Abnormal whole-brain functional network properties and abnormal intra- and inter-network FC may be related to cognitive impairment and disease degree in the non-NPSLE patients.
Study context
- Population
- SLE patients without neuropsychiatric symptoms and healthy controls
- Participants
- 32 vs 32
- Exposure
- Non-NPSLE patients vs healthy controls
- non-NPSLEn = 32
- Healthy controls (HC)n = 32reference
- Outcome
- Topological properties (global and nodal parameters) of the whole-brain functional network
Methodological detailsresting-state fMRI, graph theory analysis
- Resting-state fMRI
- Graph theory analysis
Main finding
As reported in the abstract
Whole-brain functional network topology
- Non-NPSLE vs HC: significantly lower clustering coefficient, global and local efficiency, but higher characteristic path length
- Non-NPSLE vs HC: significantly lower nodal strength in ventromedial prefrontal cortex (vmPFC) and anterior PFC (aPFC)
Observational data: associations, not effects.
Further findings
- Non-NPSLE vs HC: significantly lower intra-network functional connectivity (FC) within frontal-parietal network (FPN) and within default mode network (DMN), and lower inter-network FC between DMN and FPN
- Intra-network FC within DMN negatively correlated with systemic lupus erythematosus disease activity index (SLEDAI)
Original publication
Disrupted resting-state brain functional network properties in non-neuropsychiatric systemic lupus erythematosus patients. Lupus. Published 14 March 2023. doi:10.
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