Lupus & antiphospholipid syndrome
Interaction of 5-HTTLPR and systemic lupus erythematosus (SLE) disease status on resting-state brain function
Authors' conclusion
Brain function in the right parietal and inferior angular gyrus and the right paracentral lobule is affected by the interaction effect of SLE disease status and 5-HTTLPR genotype.
Study context
- Population
- SLE patients without obvious neuropsychiatric manifestations and healthy volunteers
- Participants
- 51 vs 44
- Comparison
- SLE patients vs healthy controls, by 5-HTTLPR genotype
- SLEn = 51
- HCn = 44reference
- Outcome
- Interaction effect of SLE disease status and 5-HTTLPR genotype on resting-state brain function (mean ReHo, ALFF, fALFF in 116 regions)
Methodological detailsresting-state fMRI, two-way analysis of covariance
- Resting-state fMRI
- Two-way analysis of covariance
Main finding
As reported in the abstract
Interaction of SLE status and 5-HTTLPR genotype on brain function
- S/S genotype: SLE lower mean regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF) in right parietal, inferior angular gyrus and right paracentral lobule vs HC; not evident among L allele carriers
Observational data: associations, not effects.
Further findings
Other regions, S/S genotype
- SLE: decreased mean ReHo in left posterior cingulate gyrus, reduced mean fALFF in left caudate nucleus, diminished mean ALFF in left temporal pole: superior temporal gyrus vs HC; no such differences among L allele carriers
Other regions, L allele carriers
- SLE: higher mean ReHo in right hippocampus and lower mean ALFF in left medial and paracingulate gyrus vs HC; not apparent among S/S homozygotes
Original publication
Interaction of 5-HTTLPR and SLE disease status on resting-state brain function. Arthritis Res Ther. Published 31 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →