Lupus & antiphospholipid syndrome
Local Ancestry at the Major Histocompatibility Complex Region is Not a Major Contributor to Disease Heterogeneity in a Multiethnic Lupus Cohort
Authors' conclusion
These findings suggest that local genetic ancestry within the Major Histocompatibility Complex region is not a major contributor to these SLE manifestations among patients with SLE from admixed populations.
Study context
- Population
- European, African American and Mestizo patients with systemic lupus erythematosus (SLE) genotyped with the Affymetrix LAT1 World array
- Participants
- 1,139 participants
- Exposure
- SLE patients with vs without lupus nephritis, younger age at onset or autoantibodies, by global and local MHC-region ancestry proportions
- Outcome
- Associations of lupus nephritis, age at onset and autoantibody status with global and local ancestry proportions within the MHC region
Methodological detailsmultiethnic cohort, global ancestry (ADMIXTURE), local ancestry (RFMIXv2.0)
- Multiethnic cohort
- Global ancestry (ADMIXTURE)
- Local ancestry (RFMIXv2.0)
Main finding
As reported in the abstract
Association of global and local MHC ancestry with SLE manifestations
- Small effect sizes, not statistically significant, for global or local ancestry proportions in African American or Mestizo patients with SLE with vs without the manifestations of interest
Observational data: associations, not effects.
Original publication
Local Ancestry at the Major Histocompatibility Complex Region is Not a Major Contributor to Disease Heterogeneity in a Multiethnic Lupus Cohort. Arthritis Rheumatol. Published 30 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →