Lupus & antiphospholipid syndrome
Single‐Cell Profiling of Bone Marrow B Cells and Early B Cell Developmental Disorders Associated With Systemic Lupus Erythematosus
Authors' conclusion
In summary, this study suggests that early B cell loss in BM defines a unique pathological state in a subset of patients with SLE that may play an active role in the dysregulated autoimmune responses.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE); Bone marrow (BM) B cells
- Comparison
- SLE with defective/low early B cells vs SLE with normal early B cells
Methodological detailssingle-cell RNA/BCR sequencing, immune profiling
- Single-cell RNA/BCR sequencing
- Immune profiling
Main finding
As reported in the abstract
- SLE-EBlo vs SLE-EBnor: more severe disease activity and proinflammatory status
- SLE-EBlo vs SLE-EBnor: overaction of type I interferon signaling and metabolic pathways within the B cell compartment
- SLE-EBlo vs SLE-EBnor: aberrant BCR repertoires
Further findings
Repeat BM sample at remission in one SLE-EBlo patient · remission phase
- Early B cell deficiency and associated abnormalities largely rectified
Original publication
Single‐Cell Profiling of Bone Marrow B Cells and Early B Cell Developmental Disorders Associated With Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 30 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →