Lupus & antiphospholipid syndrome
Altered hippocampal connectivity dynamics predicts memory performance in neuropsychiatric lupus: a resting-state fMRI study using cross-recurrence quantification analysis
Authors' conclusion
By using dynamic CRQA of the rs-fMRI data, distorted FC was found globally, as well as in medial temporal and parietal brain regions in patients with SLE, that correlated significantly and adversely with memory capacity in NPSLE.
Study context
- Population
- Patients with SLE with or without neuropsychiatric manifestations, and healthy controls
- Participants
- 44 / 20 / 35
- Exposure
- Neuropsychiatric SLE (NPSLE) vs non-NPSLE vs healthy controls
- NPSLEn = 44
- non-NPSLEn = 20
- Healthy controls (HCs)n = 35reference
- Outcome
- Whole-brain and regional functional connectivity and association with cognitive performance
Methodological detailsresting-state fMRI, cross-recurrence quantification analysis, FDR corrected
- Resting-state fMRI
- Cross-recurrence quantification analysis
- FDR corrected
Main finding
As reported in the abstract
Whole-brain functional connectivity (FC): modularity (cross-recurrence quantification analysis (CRQA) of resting-state functional MRI (rs-fMRI))
NPSLE
0.31
mean · SD 0.06
HCs
0.27
mean · SD 0.06
P = 0.05
Observational data: associations, not effects.
Further findings
| Outcome | non-NPSLE |
|---|---|
| Connectivity in non-NPSLEValues mean (SD) | |
| Right hippocampus (hypoconnectivity) | 0.056 (0.014) |
| Left angular gyrus (hyperconnectivity) | 0.25 (0.13) |
| SPL (hyperconnectivity) | 0.17 (0.12) |
Verbal episodic memory vs local efficiency, within NPSLE
- Left hippocampus, positive association r2
- 0.22, p=0.005
- Left angular gyrus, negative association r2
- 0.24, p=0.003
Original publication
Altered hippocampal connectivity dynamics predicts memory performance in neuropsychiatric lupus: a resting-state fMRI study using cross-recurrence quantification analysis. Lupus Sci Med. Published 3 July 2023. doi:10.
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