Lupus & antiphospholipid syndrome
Systemic lupus erythematosus-related acute lung disease
Authors' conclusion
Systemic lupus erythematosus-related acute respiratory failure is a severe event, mostly occurring at SLE onset, typical harboring a basal consolidation pattern on chest CT-scan and alveolar hemorrhage on BAL pathological examination. Mortality in our cohort is lower than previously reported
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and acute lung disease admitted to La Pitié-Salpêtrière Hospital, November 1996–September 2018, after exclusion of lung infection, cardiac failure or other alternate diagnosis
- Participants
- 14 patients16 episodes
- Outcome
- Clinical features, treatments and outcome of SLE-related acute lung disease
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Clinical features, treatments and outcome of SLE-related ALD
- Female
- 79%
- Age at admission, mean ± SD
- 24 ± 11 years
- Acute lung disease (ALD) inaugural of SLE
- 70%
- Episodes requiring ICU admission
- 11
- ICU stay, median
- 8 days
- Alveolar hemorrhage on bronchoalveolar lavage (when available)
- 67%
- Mechanical ventilation
- 64%
- Venovenous extracorporeal membrane oxygenation
- 18%
- Survival to ICU and hospital discharge
- All patients but one
- Relapse of SLE-related ALD
- 2
- ILD during follow-up
- 0
Observational data: associations, not effects.
Further findings
SLE main organ involvement
- Arthritis
- 93%
- Skin
- 79%
- Serositis
- 79%
- Hematological
- 79%
- Kidney
- 64%
- Neuropsychiatric
- 36%
- Cardiac
- 21%
Symptomatic respiratory treatments
- Oxygen
- 81%
- High-flow nasal canula oxygen
- 27%
- Non-invasive ventilation
- 36%
- Mechanical ventilation
- 64%
- Venovenous ECMO
- 18%
SLE-specific treatments
- GC
- 100%
- CYC
- 56%
- Plasma exchange
- 25%
Chest CT findings
- Mostly basal consolidation and ground-glass opacities
Original publication
Systemic lupus erythematosus-related acute lung disease. Lupus. Published 3 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →