Lupus & antiphospholipid syndrome
Serum lipidomic and metabolomic signatures link epicardial adipose tissue to cardiovascular diseases in SLE: a post-hoc analysis
Authors' conclusion
EAT volume is increased and associated with a distinct serum lipidomic and metabolomic signature in SLE.
Study context
- Population
- Patients with SLE followed at the French Referral Center (Pitié-Salpêtrière Hospital) who underwent a cardiac CT scan (mean age 43±14 years; 100% female)
- Participants
- 179 patients
- Outcome
- Circulating metabolomic and lipidomic signatures associated with epicardial adipose tissue (EAT) in SLE
Methodological detailsmonocentric, post-hoc analysis
- Monocentric
- Post-hoc analysis
Main finding
As reported in the abstract
EATi volume
- Mean EATi volume (mL/m²), ±SD
- 63±37
- Increased EATi volume (>68 mL/m²), n (%)
- 61 (34.1%)
- Increased EATi volume significantly associated with age, BMI, triglyceride levels, coronary artery calcium (CAC) score, prior atherosclerotic CVD and metabolites/lipid species (n)
- 47
- Key metabolites and lipid species independently associated with EATi volume (stepwise linear regression)
- 5
- AUC of lipidomic and metabolic signature for EATi volume status prediction
- 0.80 (95% CI 0.73 to 0.87)
Observational data: associations, not effects.
Original publication
Serum lipidomic and metabolomic signatures link epicardial adipose tissue to cardiovascular diseases in SLE: a post-hoc analysis. Lupus Sci Med. Published 21 April 2026. doi:10.
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