Lupus & antiphospholipid syndrome
Mortality and prognostic factors among inpatients with systemic lupus erythematosus in China: A 20-year retrospective study
Authors' conclusion
From 2002 to 2013, the mortality rate among patients with SLE fell steadily but remained unchanged from 2014 to 2022. Patients with SLE had significantly higher SMR than the general population. Childhood-onset SLE had a poorer prognosis than adult-onset SLE. Infection, MODS, and NPLE were the three leading causes of death. Major organ involvement and high disease activity were risk factors for mortality.
Study context
- Population
- Hospitalised patients with systemic lupus erythematosus (SLE) in China, January 2002 to December 2022218 deaths
- Participants
- 9,538 patients
- Comparison
- SLE inpatients who died vs randomly chosen SLE inpatient controls
- SLE death casesn = 218
- Controlsn = 110reference
- Outcome
- Causes of death, mortality and risk factors for death in SLE inpatients
Methodological detailssingle-centre, 20-year, logistic regression
- Single-centre
- 20-year
- Logistic regression
Main finding
As reported in the abstract
- Death rate, 2002
- 4.14%
- Death rate, 2013
- 1.96%
- Death rate, 2014 to 2022
- 1.84%
- Standardized mortality ratio (SMR) 2002 to 2012
- 4.98 (95% CI 4.06-5.89)
- SMR 2013 to 2022
- 3.39 (95% CI 2.74-4.04)
- Infection, share of overall deaths
- 31.19%
- Lupus-induced MODS, share of overall deaths
- 15.14%
- NPLE, share of overall deaths
- 11.47%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mortality and prognostic factors among inpatients with systemic lupus erythematosus in China: A 20-year retrospective study. Lupus. Published 12 September 2024. doi:10.
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