Lupus & antiphospholipid syndrome
Mortality among inpatients with systemic lupus erythematosus in a tertiary care hospital
Authors' conclusion
Our study highlights the significant impact of infections, particularly hospital-acquired infections, on mortality among hospitalised SLE patients.
Study context
- Population
- SLE patients (ACR 1997 or SLICC 2012 criteria) hospitalised between January 2012 and December 2021 in a tertiary care hospital; COVID-19 cases excluded
- Participants
- 111 vs 222
- Comparison
- Inpatients with SLE who died during hospitalisation vs matched controls discharged alive
- Casesn = 111
- Controlsn = 222reference
- Outcome
- In-hospital mortality: association with infection at or during hospitalisation and other predictors
Methodological detailsmatched 1:2 on age (±3 years) and sex, stratified annually, single tertiary care hospital, multivariable logistic regression
- Matched 1:2 on age (±3 years) and sex, stratified annually
- Single tertiary care hospital
- Multivariable logistic regression
Main finding
As reported in the abstract
Independent predictors of mortality (multivariable analysis)
Odds ratio (95% CI)
Infection at hospitalisation
3.37(1.85–6.13)
Pulmonary involvement
3.06(1.52–6.18)
Cardiac involvement
2.13(1.07–4.25)
Higher serum albuminprotective
0.53(0.35–0.79)
Observational data: associations, not effects.
Further findings
Infection (with or without disease activity) as cause of hospital admission
P < 0.001
Hospital mortality rate
- Hospital mortality rate
- 8.9%
Most frequent pathogen
- Acinetobacter baumannii was the most frequent pathogen
Serum creatinine as independent predictor of mortality (multivariable)
- Serum creatinine levels an independent predictor of mortality
Juvenile lupus (subgroup, n = 38)
- Similar infection-related mortality patterns
Original publication
Mortality among inpatients with systemic lupus erythematosus in a tertiary care hospital. Lupus. Published 15 July 2025. doi:10.
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