Osteoarthritis

Total Knee Arthroplasty Versus Education and Exercise for Knee Osteoarthritis: A Propensity‐Matched Analysis

Arthritis Care Res (Hoboken)Published Propensity-matched cohort study

Main finding · KOOS-12 pain, improvementResult — go to the resultMD 22.8 95% CI 19.7–25.8

Authors' conclusion

TKA is associated with greater improvements in pain, function, and quality of life

Study context

Population
Patients with knee osteoarthritis (OA)matched sample
Participants
522 patients
Exposure
Total knee arthroplasty (TKA) vs education and exercise program
  • TKAn = 261
  • Edu+Exn = 261reference
Outcome
Between-group differences in improvement (treatment effect) in KOOS-12 (0, worst to 100, best) pain, function and quality of life from baseline to 3 and 12 months
Follow-up
3 and 12 months
Methodological detailspropensity-score matched (1:1), linear mixed models
  • Propensity-score matched (1:1)
  • Linear mixed models

Main finding

KOOS-12 pain, improvement · 12 months

MD

22.8

95% CI 19.7–25.8

TKAvs Edu+Ex
MD 22.8 (95% CI 19.7–25.8)

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeMD
KOOS-12 function, improvement · 12 months21.2 (95% CI 17.7–24.4)
KOOS-12 quality of life, improvement · 12 months18.3 (CI 15.0–21.6)
OutcomeTKAEdu+Ex
Clinically meaningful improvement in outcomes · 12 months75%at least one-third

Original publication

Total Knee Arthroplasty Versus Education and Exercise for Knee Osteoarthritis: A Propensity‐Matched Analysis. Arthritis Care Res (Hoboken). Published 1 February 2024. doi:10.1002/acr.25293

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