Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis
Authors' conclusion
The negative effect of depressive symptoms on physical function may decrease over time as knee OA progresses.
Study context
- Population
- Participants from the Osteoarthritis Initiative with radiographic knee osteoarthritis (OA) and complete data
- Participants
- 2,212 participants
- Outcome
- Physical function: 20-meter gait speed (m/s), by time-varying depressive symptoms (CES-D)
- Follow-up
- First four visits
Methodological detailsmarginal structural models, time-varying exposure
- Marginal structural models
- Time-varying exposure
Main finding
As reported in the abstract
Gait speed per higher CES-D score, time-adjusted (main effect)
Higher CES-D scores significantly associated with slower gait speed: estimate
−0.0048
95% CI −0.0082 to −0.0014
Observational data: associations, not effects.
Further findings
Gait speed per higher CES-D score, time-specific, first follow-up interval (largest)
- Time-specific association of CES-D with gait speed
- −0.0082 (95% CI −0.0128 to −0.0035)
Gait speed, subsequent follow-up time points
- Influence of depressive symptoms on gait speed diminished
Original publication
Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis. Arthritis Care Res (Hoboken). Published 31 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →