The Relation of Within‐Day Physical Activity Patterns With All‐Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative
Primary result · All-cause mortalityResult — go to the resultAdjusted hazard ratio 2.09 95% CI 1.15–3.80Authors' conclusion
Unique within-day patterns of physical activity were associated with risk of death. Those with inactivity in the morning and evening were at increased risk for death.
Study context
- Population
- Adults with or at high risk for knee osteoarthritis (OA) (Osteoarthritis Initiative)
- Participants
- 1,927 adults
- Comparison
- Low activity in the morning and evening vs the average activity pattern of the sample
- Primary endpoint
- All-cause mortality
- Follow-up
- Up to eight years
Methodological detailsmultidimensional (14-hour) multilevel (4-day) functional principal component analysis of accelerometer data, Cox proportional hazards regression
- Multidimensional (14-hour) multilevel (4-day) functional principal component analysis of accelerometer data
- Cox proportional hazards regression
Primary result
As reported in the abstract
Adjusted hazard ratio
2.09
95% CI 1.15–3.80
Low morning and evening activityvs Average activity pattern
aHR 2.09 (95% CI 1.15–3.80)
Further findings
Within-day activity patterns identified
- Four primary within-day activity patterns accounting for around 82% of sample variability
Original publication
The Relation of Within‐Day Physical Activity Patterns With All‐Cause Mortality in Adults With Knee Osteoarthritis: Findings From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). Published 8 April 2026. doi:10.
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