The relation of activity patterns with incident slow gait speed over 4 years in adults with knee osteoarthritis: Data from the Osteoarthritis Initiative
Authors' conclusion
Daily activity patterns may be related to the development of slow gait speed in adults with or at risk for knee OA.
Study context
- Population
- Adults with or at high risk of knee osteoarthritis (OA) without slow gait speed at baseline (walked > 1.0 m/s during a 20-meter walk), Osteoarthritis Initiative
- Exposure
- Top and bottom tertiles of activity-pattern principal component (PC) scores vs middle tertile
- Outcome
- Incident slow gait speed
- Follow-up
- 4 years
Methodological detailssecondary analysis of Osteoarthritis Initiative data, accelerometer (ActiGraph GTM1), multilevel functional principal components analysis, adjusted for potential confounders
- Secondary analysis of Osteoarthritis Initiative data
- Accelerometer (ActiGraph GTM1)
- Multilevel functional principal components analysis
- Adjusted for potential confounders
Main finding
As reported in the abstract
Each group vs middle tertileRelative risk (95% CI)
PC2 top tertile
0.60(0.37–0.96)
PC4 top tertile
0.39(0.22–0.71)
PC3 bottom tertile
1.77(1.19–2.62)
Observational data: associations, not effects.
Original publication
The relation of activity patterns with incident slow gait speed over 4 years in adults with knee osteoarthritis: Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. Published 6 June 2025. doi:10.
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