Relation of pain sensitization to knee loading during walking in people with knee osteoarthritis
Authors' conclusion
Greater pain sensitivity, as assessed by PPT, was related to lower frontal plane joint loading during walking.
Study context
- Population
- Participants with symptomatic knee osteoarthritis (OA) enrolled in two clinical trials
- Participants
- 104 participants
- Exposure
- Lowest and middle vs highest sex-specific tertiles of pressure pain threshold (PPT)
- Outcome
- Knee joint loading during walking (peaks and impulse of KAM and knee flexion moment; frontal and sagittal plane range of motion during stance)
Methodological detailsbaseline data from two clinical trials, Analysis of Covariance (ANCOVA) adjusted for age, sex, body height and body weight, sensitivity analyses additionally adjusted for gait speed
- Baseline data from two clinical trials
- ANCOVA adjusted for age, sex, body height and body weight
- Sensitivity analyses additionally adjusted for gait speed
Main finding
As reported in the abstract
Knee loading (KAM) by PPT tertile
- Lowest tertile · knee PPT; lower 1st peak of knee adduction moment (KAM)
- ∆ 9.1 Nm (95% CI 0.3–17.9)
- Lowest tertile · wrist PPT; lower 1st peak of KAM
- ∆ 9.1 Nm (95% CI 1.3–16.8)
- Lowest tertile · wrist PPT; lower 2nd peak of KAM
- ∆ 7.5 Nm (95% CI 0.5–14.6)
- Lowest tertile · wrist PPT; lower KAM impulse
- ∆ 1.7 Nm*s (95% CI 0.1–3.2)
- Middle tertile · wrist PPT; lower 2nd peak of KAM
- ∆ 8.0 Nm (95% CI 0.7–15.4)
- Middle tertile · wrist PPT; lower KAM impulse
- ∆ 2.0 Nm*s (95% CI 0.4–3.6)
Observational data: associations, not effects.
Further findings
Sensitivity analysis adjusted for gait speed
- Effect sizes remained similar after adjusting for gait speed
Original publication
Relation of pain sensitization to knee loading during walking in people with knee osteoarthritis. Osteoarthritis Cartilage. Published 4 February 2025. doi:10.
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