Lipidomics unravels lipid changes in osteoarthritis articular cartilage
Authors' conclusion
Our study maps the hAC lipid composition and highlights changes in lipid profiles associated with OA. Dysregulation of certain lipids, especially odd-chain fatty acids, linked to a deficiency in the enzyme HACL1, leads to pathological changes.
Study context
- Population
- Human articular chondrocytes (hACs) from non-OA and osteoarthritis (OA) hips; Destabilisation of the medial meniscus (DMM) mouse model
- Participants
- 14 vs 13
- Comparison
- OA vs non-OA human articular chondrocytes
- OAn = 14
- Non-OAn = 13reference
- Outcome
- Lipid composition of hACs, OA vs non-OA
Methodological detailslipidomic profiling, computational analyses, DMM mouse model, in vitro supplementation and gene silencing
- Lipidomic profiling
- Computational analyses
- DMM mouse model
- In vitro supplementation and gene silencing
Main finding
As reported in the abstract
- Lipid species identified in hACs (covering 11 lipid classes)
- 573
Original publication
Lipidomics unravels lipid changes in osteoarthritis articular cartilage. Ann Rheum Dis. Published 1 February 2025. doi:10.
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