Acute loading has minor influence on human articular cartilage gene expression and glycosaminoglycan composition in late-stage knee osteoarthritis: a randomised controlled trial
Authors' conclusion
Acute exercise had minor influence on cartilage GAG dynamics, indicating that osteoarthritic cartilage is not significantly affected by acute exercise.
Study context
- Population
- Patients with primary knee osteoarthritis (OA) scheduled for joint replacement surgery; mean age 69 ± 7.5 years (SD), 58% female, BMI 29.4 ± 4.4 kg/m²31 completed the intervention
- Participants
- 32 patients
- Comparison
- One bout of resistance exercise (one-legged leg press) 3.5 h before knee replacement vs no loading
- Primary endpoint
- Gene expression and GAG content in human OA cartilage after acute loading
Methodological detailssingle-blind
- Single-blind
Primary result
As reported in the abstract
- Cartilage relevant gene expression was unchanged
- Exercise vs No loading: 95% CI 1.01–2.46; P = 0.0486
Further findings
Regional differences: submeniscal vs central condylar cartilage
- Submeniscal area showed higher MMP-3, MMP-13, IGF-1Ea and CTGF, and lower lubricin and COMP expression, than central condylar region
- Central condylar hyaluronidase-extracted matrix contained more GAGs but less chondroitin sulphate than submeniscal cartilage
Regional differences: osteophyte vs articular cartilage
- Osteophyte expression of MMP-1, MMP-13, IGF-1Ea and TGF-β3 higher, and of aggrecan, COMP and FGF-2 lower, than articular cartilage
Original publication
Acute loading has minor influence on human articular cartilage gene expression and glycosaminoglycan composition in late-stage knee osteoarthritis: a randomised controlled trial. Osteoarthritis Cartilage. Published 30 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →